Auto Immune Disease
Auto Immune Disorder = Introduction
Auto Immune Disorders – series of adverse responses of the body to its own tissue. The body is attacked by it’s own defense system.
The immune system, when triggered by stressful elements, views it’s own body tissue as foreign and attacks for destruction, thereof.
Evident in diseases such as, Type I Diabetes, Systematic Lupus Erythematosus, Cardiomyopathy, Graves Disease (hyperactive thyroid), Ulcerative Colitis, Multiple Sclerosis, Rheumatoid Arthritis etc.
A major trigger for the causation of auto immune disorders is climate change.
Extreme temperatures exert a tremendous impact upon biological physiology.
Other environmental contaminants and by products of human behavior having a direct effect upon individuals are cigarette smoke, automobile exhaust fumes etc.
Hyper excitation of the immune system effectuates a derailment of usually positive mediated reactions whereby the body’s defenses looses sight of it’s own defenses and attacks it’s own body’s tissue with purpose for destruction, thereof.
Phagocytosis of viable tissue replaces the destruction of foreign, invasive protein elements.
An analytic study by the Multiple Autoimmune Disease Genetic Consortium, (MADGC), Criswell etal (2005), was made and demonstrated that at least two of nine core diseases were present in each family researched, indicating a familial susceptibility to auto immune disorders.
The core diseases were rheumatoid arthritis, systemic lupus erythematosus, type I diabetes, multiple sclerosis, Graves disease, juvenile RA, ulcerative colitis, psoriasis, and Sjogren syndrome.
The objectives of this presentation are:
Reference
The immune system, when triggered by stressful elements, views it’s own body tissue as foreign and attacks for destruction, thereof.
Evident in diseases such as, Type I Diabetes, Systematic Lupus Erythematosus, Cardiomyopathy, Graves Disease (hyperactive thyroid), Ulcerative Colitis, Multiple Sclerosis, Rheumatoid Arthritis etc.
A major trigger for the causation of auto immune disorders is climate change.
Extreme temperatures exert a tremendous impact upon biological physiology.
Other environmental contaminants and by products of human behavior having a direct effect upon individuals are cigarette smoke, automobile exhaust fumes etc.
Hyper excitation of the immune system effectuates a derailment of usually positive mediated reactions whereby the body’s defenses looses sight of it’s own defenses and attacks it’s own body’s tissue with purpose for destruction, thereof.
Phagocytosis of viable tissue replaces the destruction of foreign, invasive protein elements.
An analytic study by the Multiple Autoimmune Disease Genetic Consortium, (MADGC), Criswell etal (2005), was made and demonstrated that at least two of nine core diseases were present in each family researched, indicating a familial susceptibility to auto immune disorders.
The core diseases were rheumatoid arthritis, systemic lupus erythematosus, type I diabetes, multiple sclerosis, Graves disease, juvenile RA, ulcerative colitis, psoriasis, and Sjogren syndrome.
The objectives of this presentation are:
- Understanding of the relationship of humankind and environment
- Determination of a sustainable plan for attainment of optimal wellbeing, for those with a diagnosis of Auto Immune Disorder
- Advocation for regulatory controls of climatic transformations.
Reference
- Criswell, L., Pfeiffer, K., Lum, R., Gonzales, B., Novitzke, J., Kern, M., Moser, L., Begovivich, A., Carlton, V., Wentian, L., Lee, A., Ortmann, W., Behrens, T., Gregersen, P.
Auto Immune Stress Disorder
Definitions
Definitions
Allele-1, 2 or more alternative forms of a gene that arises by mutation and found at the same place on a gene on a chromosome
Antigen-toxin (foreign substance), when introduced into the body (usually by bacteria or virus) induces an immune response
Apoptosis-normal cell death occurring as a controlled part of an organism’s development
Auto Immunity Disorders-over activity of the immune system, whereby the body attacks and destroys it’s own tissue
Antibody (Ig immune globin) large y shaped protein produced by plasma cells and used by immune system to neutralize and destroy pathogens (bacteria and viruses)
B cells- secretes antibodies and mature in bone marrow
Chromosome-DNA of a molecule with part or all of genetic material (genome) of an organism
Cytokines-small proteins; important in cell signaling; immune modulating agents; modulate balance between humoral and cell based immune responses
DNA-Deoxyribonucleic acid-self replicating material; present in nearly all living organisms.
It is the main constituent of chromosomes; carrier of genetic information
Genotype-genetic make up of an organism with reference to a specific trait or complex of traits
Molecule-group of atoms bonded together, representing the smallest fundamental unit of a chemical compound that can partake in a chemical reaction
Ontogenesis-development of an individual organism or anatomical or behavioral feature from the earliest stage to maturity (phylogenesis)
Phagocytes-cells that protect the body by ingesting harmful foreign particles (bacteria) or dead, dying cells
Phagocytosis-ingestion of bacteria and other relative material by phagocytes and ameboid protozoa
Phenotype-set of observable characteristics of an individual resulting from interaction with environment of its genotype
T cells-cell mediated immunity; helps with maturation of B cells; activates cytotoxic T cells and macrophages
Trait-distinct characteristics or quality of a person
Antigen-toxin (foreign substance), when introduced into the body (usually by bacteria or virus) induces an immune response
Apoptosis-normal cell death occurring as a controlled part of an organism’s development
Auto Immunity Disorders-over activity of the immune system, whereby the body attacks and destroys it’s own tissue
Antibody (Ig immune globin) large y shaped protein produced by plasma cells and used by immune system to neutralize and destroy pathogens (bacteria and viruses)
B cells- secretes antibodies and mature in bone marrow
Chromosome-DNA of a molecule with part or all of genetic material (genome) of an organism
Cytokines-small proteins; important in cell signaling; immune modulating agents; modulate balance between humoral and cell based immune responses
DNA-Deoxyribonucleic acid-self replicating material; present in nearly all living organisms.
It is the main constituent of chromosomes; carrier of genetic information
Genotype-genetic make up of an organism with reference to a specific trait or complex of traits
Molecule-group of atoms bonded together, representing the smallest fundamental unit of a chemical compound that can partake in a chemical reaction
Ontogenesis-development of an individual organism or anatomical or behavioral feature from the earliest stage to maturity (phylogenesis)
Phagocytes-cells that protect the body by ingesting harmful foreign particles (bacteria) or dead, dying cells
Phagocytosis-ingestion of bacteria and other relative material by phagocytes and ameboid protozoa
Phenotype-set of observable characteristics of an individual resulting from interaction with environment of its genotype
T cells-cell mediated immunity; helps with maturation of B cells; activates cytotoxic T cells and macrophages
Trait-distinct characteristics or quality of a person
GENETICS
AUTO IMMUNE DISORDERS
AUTO IMMUNE DISORDERS
Occurrence of different autoimmune disorders within the same family suggests that certain susceptibility genes predisposes to a variety of auto immune disorders.
Genetic mapping begins the identification of chromosomal regions that predispose to specific autoimmune disorders
The most consistent association for susceptibility to an auto immune disorder has been with identification of specific alleles (gene mutations) within the major histo compatibility complex ((MHC) (histological or body tissue structure
It has been suggested that the association of MHC genotype with autoimmune disease relates to differences in the ability of different allelic (mutated gene formations) variations of MHC molecules to present auto antigenic peptides to reactive T cells…. (trigger for T cells to self destruct)
An alternative hypothesis involves the role of MHC alleles in shaping the T cells receptors repertoire during T cell ontogenesis in the thymus
Additionally, specific MHC gene products maybe themselves the source of peptides that can be recognized by T cells
Cross reactivity between MHC peptides and peptides derived from proteins produced by common microbes may trigger auto immunity by molecular mimicry
Evidence exists that MHC genotype alone does not determine the development of auto immunity, e.g. identical twins are far more likely to develop the same auto immune disorder than non twin siblings, suggesting that genetic factors, other than MHC also affect disease susceptibility
There is suggestive evidence that several other genes are important with increasing susceptibility to auto immune disease in humans e.g. inherited homozygous deficiency of early proteins in the classic pathway of complement C1, C$, or C2-strongly associated with the development of Systemic Lupus Erythematosus.
There is also evidence that inherited variations in the level of certain cytokines may increase susceptibility
Inheritance Pattern:
CVID: Common Variable Immune Deficiency-most cases are sporadic and occur in people with no apparent history
Occurrence often due to complex interaction of environment and genetic factor
Rare cases-inherited in autosomal recessive pattern in which both copies of a gene in each cell have mutations; each parent carries copies of mutated genes but do not demonstrate signs and symptoms
Counseling:
Mignon Smith
Genetic mapping begins the identification of chromosomal regions that predispose to specific autoimmune disorders
The most consistent association for susceptibility to an auto immune disorder has been with identification of specific alleles (gene mutations) within the major histo compatibility complex ((MHC) (histological or body tissue structure
It has been suggested that the association of MHC genotype with autoimmune disease relates to differences in the ability of different allelic (mutated gene formations) variations of MHC molecules to present auto antigenic peptides to reactive T cells…. (trigger for T cells to self destruct)
An alternative hypothesis involves the role of MHC alleles in shaping the T cells receptors repertoire during T cell ontogenesis in the thymus
Additionally, specific MHC gene products maybe themselves the source of peptides that can be recognized by T cells
Cross reactivity between MHC peptides and peptides derived from proteins produced by common microbes may trigger auto immunity by molecular mimicry
Evidence exists that MHC genotype alone does not determine the development of auto immunity, e.g. identical twins are far more likely to develop the same auto immune disorder than non twin siblings, suggesting that genetic factors, other than MHC also affect disease susceptibility
There is suggestive evidence that several other genes are important with increasing susceptibility to auto immune disease in humans e.g. inherited homozygous deficiency of early proteins in the classic pathway of complement C1, C$, or C2-strongly associated with the development of Systemic Lupus Erythematosus.
There is also evidence that inherited variations in the level of certain cytokines may increase susceptibility
Inheritance Pattern:
CVID: Common Variable Immune Deficiency-most cases are sporadic and occur in people with no apparent history
Occurrence often due to complex interaction of environment and genetic factor
Rare cases-inherited in autosomal recessive pattern in which both copies of a gene in each cell have mutations; each parent carries copies of mutated genes but do not demonstrate signs and symptoms
Counseling:
- Diet: Whole unprocessed foods
- Testing: Food allergies
- Monitor and control infections and microbial growth
- Reseed inner ecosystem: use pre and probiotic rich foods e.g. plain yogurt, sauerkraut
- Include omega 3, glutamine and zinc
- Avoid extreme temperatures and ultra violet rays
Mignon Smith